DCA is available very cheaply, from commercial vendors like Sigma Aldrich (1gm pure drug for~ $16). I have actually worked with this drug in a lab setting. I cannot verify if it has any clinical advantage. The way it works is simple – it inhibits an enzyme called pyruvate dehydrogenase kinase (PDK) which is responsible in reducing the activity of the enzyme (group) pyruvate dehydrogenase (PDH). The activity of PDH is drastically reduced in some (~20 – 30%) type of cancers (eg. neck and squamous cell cancer). In these cases, DCA will restore the activity of PDH – restore the metabolism of the mitochondria – ultimately allowing the cancer cell to undergo apoptosis, or cell death.
If I had cancer, I would buy this for myself and administer it no matter what. Keep in mind any (every) drug/chemical has a threshold, which if crossed will make the drug toxic. From the company (Sigma) website: LD50 Oral – rat – 2,820 mg/kg – meaning about 3 grams of DCA per Kilogram of body mass can kill 50 rats out of a sample of 100. Humans will have a different tolerance. Compared to some drugs out there that are either expensive as diamonds or have side effects like heck, this is definitely worth a shot. Why companies won’t touch it is pretty obvious, why you and me shouldn’t try it doesn’t make sense. Some other side effects are skin irritation and a potential damage to mucosal layer in the mouth, nose and gut (you’ve been warned).
One last thing – there are some legit researchers sounding off here, and I agree with them. They ARE voices of reason and statistics. For those who vehemently attack them, get a life, there are some over here seeking actual answers and not some ideological argument material. The author of this article did a poor job of conveying the message, but the message may have some truth.
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The recommended dose of DCA is 20/mg per kilogram of body weight.
This is less than 1% of the dangerous dose. DCA is incredibly safe to use at the recommended 20mg/kg of body weight level.