FAQ Categories Archives: Side Effects

What is TLS?

Tumor lysis syndrome, TLS is a serious complication of antitumor therapy, often leading to kidney failure, multiorgan failure and death. Most cases of TLS happen when during chemotherapy of those tumors, which are very responsive to cytostatics (Burkitt’s lymphoma, acute lymphoblastic leukemia, hepatoblastoma, neuroblastoma).  It is caused by a sudden disintegration (necrosis or massive apoptosis) of cancer cells, which release large amounts of potassium, uric acid and phosphor.

The excess of uric acid, potassium and phosphor is excreted by kidneys. These amounts, however, are significant enough to cause hyperkalemia, hyperuricemia, heperphosphatemia followed by hypercalcemia.  In the acidic kidney urethra environment, the uric acid precipitates and may remain in the organism, stopping the excreting of urine and consequently leading to kidney failure.

Some of the symptoms include: stomachache; anuria, oliguria, hematuria, colic pain; symptoms of hypercalcemia – vomiting, lack of appetite, tetany; symptoms of hyperkalemia – weakness, paralysis, cardiac conduction abnormalities.

Complications: acute kidney failure; ventricular arrhythmia followed by hyperkalemia; heart failure in extreme cases of hyperkalemia.

Continue Reading

Are there Any Side Effects of DCA Treatment?

Yes, there can be.   DCA may cause reversible damage to peripheral nerves. The symptoms include trembling of fingers and toes. The doctors stress again that this damage IS reversible.  In order to work against neuropathy you should use the dietary supplements mentioned above.

Other possible temporary side effects include:

–  vertigo, depression, fatigue (especially noticeable if DCA is administered with caffeine), weakness (especially noticeable if DCA is administered with caffeine), increased urination, swelling in the ankle area, nausea, anxiety

If the side effects would become hard to cope with, it may mean that the dosage of DCA should be lowered or that DCA should not be administered for a few days.

Side effects observed in patients by the doctors from Medicor Cancer Centers:

Neurological: Damage to nerves in hands and feet (peripheral neuropathy).  Neuropathy usually needs several weeks to develop and if it is detected early, it is reversible. According to the existing literature, neuropathy resulting from DCA treatment on age.   In order to prevent and/or reduce the severity of peripheral neuropathy, take a B1 vitamin (benfothiamin or thiamin) and Acid R(+) alpha lipon acid.

Drug intoxication, disorientation, hallucinations, memory-related problems, trembling hands. These side effects seem to be dependent on the dosage and age of a patient.  It is in accordance with the existing examination data from the patients.

Gastrointestinal: Heartburn, nausea, vomiting, indigestion. These side effects may appear during DCA treatment. The doctors prescribe proton pomp inhibitor (e.g. pantoprazole) in order to prevent them.

Other side effects: Some patients feel pain in the vicinity of tumor(s) during the first few days from the beginning of DCA treatment. This seems to show that the DCA is working.

Most of the reported side effects are of mild or moderate intensification.

Continue Reading